Cinanserin hydrochloride
Cat. No.：YN320091
CAS No. ：54-84-2
| 产品名称: | Cinanserin hydrochloride |
| CAS No.: | 54-84-2 |
| Chemical Name: | N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide, monohydrochloride |
| Synonyms: | SQ 10643 |
| 分子量: | 376.94 |
| 分子式: | C₂₀H₂₅ClN₂OS |
| SMILES: | O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cinanserin hydrochloride (SQ 10643) 是一种有效，选择性和高度亲和力的5-HT2受体拮抗剂，Ki为 41 nM。Cinanserin hydrochloride 对5-HT2的结合亲和力比对 5-HT1受体 (Ki为 3500 nM) 的结合亲和力高得多。Cinanserin hydrochloride 还是严重急性呼吸系统综合症冠状病毒的 3C 样蛋白酶 (3C-like proteinase) 的抑制剂，可大大减少体外的病毒复制。 |
| IC50和靶点: | [{name:"5-HT2 Receptor:41 nM (Ki)'}, '3C-like proteinase'] |
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Rubin, B., Piala, J.J., Burke, J.C., et al.A new, potent, and specific serotonin inhibitor (SQ 10,643) 2' -(3 - dimethylaminopropylthio)cinnamanilide hydrochloride: Antiserotonin activity on uterus and on gastrointestinal, vascular, and respiratory systems of animalsArch. Int. Pharmacodyn. Ther.152,132-143(1964)
Rosen, A.J., and Cohen, M.E.The effects of cinanserin, a potent serotonin antagonist, on the acquisition of a running response in the ratNeuropharmacology12(6),501-508(1973)
Chen, L., Gui, C., Luo, X., et al.Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitroJ. Virol.79(11),7095-7103(2005)
K.H., C., Phoon, M.C., Putti, T., et al.Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infectionAsian Pac. J. Trop. Med.9(1),1-7(2016)
