Spiramide
Cat. No.：YN320094
CAS No. ：510-74-7
| 产品名称: | Spiramide |
| CAS No.: | 510-74-7 |
| Chemical Name: | 8-[3-(p-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; Fluroxyspiramine; Spiramide; |
| Synonyms: | AMI-193 |
| 分子量: | 383.46 |
| 分子式: | C₂₂H₂₆FN₃O₂ |
| SMILES: | O=C1NCN(C2=CC=CC=C2)C13CCN(CCCOC4=CC=C(F)C=C4)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Spiramide (AMI-193) 是一种有效和选择性的5-HT2和dopamine D2受体拮抗剂，Ki值分别为 2 nM 和 3 nM。Spiramide 对 5-HT2 受体的选择性与5-HT1C受体 (Ki=4300 nM) 相比大于 2000 倍。Spiramide 具有抗精神病活性。 |
| IC50和靶点: | [{name:"5-HT2 Receptor:2 nM (Ki)"},{name: "D2 Receptor:3 nM (Ki)"},{name: "5-HT1A Receptor:50 nM (Ki)"},{name: "D1 Receptor:2530 nM (Ki)"},{name: "5-HT1C Receptor:4300 nM (Ki)"}] |
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Luparini, M. R., et al.: Prog. Neuropsychopharmacol. Biol. Psychiatry, 28, 1117-1127 (2004)
Bi, K., et al.: Anal. Bioanal. Chem., 407, 5343-5351 (2015)
Fujieda, N., et al.: J. Biol. Inorg. Chem., 18, 19 (2013)
