Asenapine
Cat. No.：YN320112
| 产品名称: | Asenapine |
| CAS No.: | 65576-45-6 |
| Chemical Name: | rel-5-chloro-2,3,3aR,12bR-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
| Synonyms: | 阿塞那平; Org 5222 |
| 分子量: | 285.77 |
| 分子式: | C₁₇H₁₆ClNO |
| SMILES: | ClC1=CC=C2OC3=CC=CC=C3[C@@](C4)([H])[C@](CN4C)([H])C2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Asenapine 是 5-羟色胺受体 (serotonin receptor)、肾上腺素受体 (adrenoceptors)、多巴胺受体 (dopamine receptors) 和组胺受体 (histamine receptors) 多种受体的拮抗剂，对它们作用的pKi值的范围分别为 8.4-10.5、8.9-9.5、8.9-9.4 和 8.2-9.0。Asenapine 具有抗精神病活性，可用于精神分裂症和双相情感障碍的研究。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:8.6 (pKi)"},{name: "5-HT1B Receptor:8.4 (pKi)"},{name: "5-HT2A Receptor:10.2 (pKi)"},{name: "5-HT2B Receptor:9.8 (pKi)"},{name: "5-HT2C Receptor:10.5 (pKi)"},{name: "5-HT5 Receptor:8.8 (pKi)"},{name: "5-HT6 Receptor:9.6 (pKi)"},{name: "5-HT7 Receptor:9.9 (pKi)"},{name: "Alpha-2A adrenergic receptor:8.9 (pKi)"},{name: "α1-adrenergic receptor:8.9 (pKi)"},{name: "Alpha-2B adrenergic receptor:9.5 (pKi)"},{name: "Alpha-2C adrenergic receptor:8.9 (pKi)"},{name: "D1 Receptor:8.9 (pKi)"},{name: "D2 Receptor:8.9 (pKi)"},{name: "D3 Receptor:9.4 (pKi)"},{name: "D4 Receptor:9.0 (pKi)"},{name: "H1 Receptor:9.0 (pKi)"},{name: "H2 Receptor:8.2 (pKi)"}] |
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Ghanbari, R., El Mansari, M., Shahid, M., et al.Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, α2-adrenergic and D2 receptors in the rat brainEur. Neuropsychopharmacol.19(3),177-187(2009)
Shahid, M., Walker, G.B., Zorn, S.H., et al.Asenapine: A novel psychopharmacologic agent with a unique human receptor signatureJ. Psychopharmacol.23(1),65-73(2009)
Frånberg, O., Wiker, C., Marcus, M.M., et al.Asenapine, a novel psychopharmacologic agent: Preclinical evidence for clinical effects in schizophreniaPsychopharmacol. (Berl)196(3),417-429(2008)
McLean, S.L., Neill, J.C., Idris, N.F., et al.Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the ratBehav. Brain Res.214(2),240-247(2010)
