SR 57227A
Cat. No.：YN320218
CAS No. ：77145-61-0
| 产品名称: | SR 57227A |
| CAS No.: | 77145-61-0 |
| Chemical Name: | 1-(6-chloro-2-pyridinyl)-4-piperidinamine, monohydrochloride |
| Synonyms: | SR57227盐酸盐,SR 57227 hydrochloride |
| 分子量: | 248.15 |
| 分子式: | C₁₀H₁₅Cl₂N₃ |
| SMILES: | ClC1=NC(N2CCC(N)CC2)=CC=C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SR 57227A 是具有口服活性的5-HT3受体的一种选择性激动剂, 可透过血脑屏障。SR 57227A 对大鼠皮质膜和整个 NG 108-15 细胞或其膜上 5-HT3 受体结合位点的亲和力 (IC50) 在 2.8~250 nM。具有抗抑郁作用。 |
| IC50和靶点: | |
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Bachy, A., Héaulme, M., Giudice, A., et al.SR 57227A: A potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivoEur. J. Pharmacol.237(2-3),299-309(1993)
Poncelet, M., Pério, A., Simiand, J., et al.Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodentsJ. Neural Transm. Gen. Sect.102(2),83-90(1995)
