SB 243213 dihydrochloride
Cat. No.：YN320235
CAS No. ：1780372-25-9
| 产品名称: | SB 243213 dihydrochloride |
| CAS No.: | 1780372-25-9 |
| Chemical Name: | 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-indole-1-carboxamide, dihydrochloride |
| Synonyms: | |
| 分子量: | 501.33 |
| 分子式: | C₂₂H₂₁Cl₂F₃N₄O₂ |
| SMILES: | O=C(N1CCC2=C1C=C(C(F)(F)F)C(C)=C2)NC3=CC=C(OC4=CC=CN=C4C)N=C3.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB 243213 dihydrochloride 是一种口服有效的，选择性的，高亲和力的5-HT2C受体拮抗剂，对人 5-HT2C受体的pKi为 9.37，pKb为 9.8。SB 243213 dihydrochloride 对多种神经递质受体、酶和离子通道具有超过 100 倍的选择性。SB 243213 dihydrochloride 具有改善的抗焦虑特性，有用于精神分裂症和运动障碍的潜力。 |
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Bromidge, S.M., Dabbs, S., Davies, D.T., et al.Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agentJ. Med. Chem.43(6),1123-1134(2000)
