PU02
Cat. No.：YN320237
CAS No. ：313984-77-9
| 产品名称: | PU02 |
| CAS No.: | 313984-77-9 |
| Chemical Name: | 6-[(1-naphthalenylmethyl)thio]-9H-purine |
| Synonyms: | 6-[(1-Naphthalenylmethyl)thio]-9H-purine,PU-02 |
| 分子量: | 292.36 |
| 分子式: | C₁₆H₁₂N₄S |
| SMILES: | C12=NC=NC(SCC3=C4C=CC=CC4=CC=C3)=C1N=CN2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PU02 是 6-MP (HY-13677) 的一个衍生物，是5-HT3受体的负变构调节剂，其在 HEK293 细胞测得的转染 5-HT3A 和 5-HT3AB 受体后的IC50值分别为 0.36 和 0.73 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Trattnig, S.M., Harpsøe, K., Thygesen, S.B., et al.Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit siteJ. Biol. Chem.287(30),25241-25254(2012)
Yang, X.-G., Bao, Y.-L., Huang, Y.-X., et al.6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cellsEur. J. Pharmacol.695(1-3),27-33(2012)
