(Rac)-WAY-161503
Cat. No.：YN320241
CAS No. ：75704-24-4
| 产品名称: | (Rac)-WAY-161503 |
| CAS No.: | 75704-24-4 |
| Chemical Name: | 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one |
| Synonyms: | |
| 分子量: | 272.13 |
| 分子式: | C₁₁H₁₁Cl₂N₃O |
| SMILES: | O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (Rac)-WAY-161503 是一种有效的，选择性的，高亲和力的5-HT2C受体激动剂，Ki为 4 nM，EC50为 12 nM。(Rac)-WAY-161503 对HT2C的亲和力分别比 5-HT2A和 5-HT2B受体高。(Rac)-WAY-161503 具有抗肥胖和抗抑郁的作用。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Rosenzweig-Lipson, S., Zhang, J., Mazandarani, H., et al.Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503Brain Res.1073-1074,240-251(2006)
Cryan, J.F., and Lucki, I.Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptorsJ. Pharmacol. Exp. Ther.295(3),1120-1126(2000)
Hayes, D.J., Mosher, T.M., and Greenshaw, A.J.Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in ratsBehav. Brain Res.197(2),323-330(2009)
