AS19
Cat. No.：YN320242
| 产品名称: | AS19 |
| CAS No.: | 1000578-26-6 |
| Chemical Name: | 1,2S,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-naphthalenamine |
| Synonyms: | |
| 分子量: | 283.41 |
| 分子式: | C₁₈H₂₅N₃ |
| SMILES: | CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AS19 是一种有效的选择性5-HT7受体激动剂，IC50值为 0.83 nM，Ki为 0.6 nM。AS19 对5-HT7的选择性高于 5-HT1A，5-HT1B，5-HT1D和 5-HT5A受体 (Kis 分别为 89.7 nM，490 nM，6.6 nM 和 98.5 nM)。AS19 可增强记忆力，并逆转由 Scopolamine 或 Dizocilpine 引起的健忘症。 |
| IC50和靶点: | [{name:"Human 5-HT7 Receptor:0.83 nM (IC50)"},{name: "Human 5-HT7 Receptor:0.6 nM (Ki)"},{name: "5-HT1A Receptor:89.7 nM (Ki)"},{name: "5-HT1B Receptor:490 nM (Ki)"},{name: "5-HT1D Receptor:6.6 nM (Ki)"},{name: "5-HT5 Receptor:98.5 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Brenchat, A., Romero, L., García, M., et al.5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in micePain141(3),239-247(2009)
Perez-García, G.S., and Meneses, A.Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning taskBehav. Brain Res.163(1),136-140(2005)
Li, S.-F., Zhang, Y.-Y., Li, Y.-Y., et al.Antihyperalgesic effect of 5-HT7 receptor activation on the midbrain periaqueductal gray in a rat model of neuropathic painPharmacol. Biochem. Behav.127,49-55(2014)
