GR 113808
Cat. No.：YN320243
CAS No. ：144625-51-4
| 产品名称: | GR 113808 |
| CAS No.: | 144625-51-4 |
| Chemical Name: | 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester |
| Synonyms: | 1H-Indole-3-carboxylicacid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester;[1-[2-(methanesulfonamido)ethyl]piperidin-4-yl]methyl 1-methylindole-3-carboxylate;1H-Indole-3-carboxylicacid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]et |
| 分子量: | 393.50 |
| 分子式: | C₁₉H₂₇N₃O₄S |
| SMILES: | O=C(C1=CN(C)C2=C1C=CC=C2)OCC3CCN(CCNS(=O)(C)=O)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GR 113808 是一种有效且高度选择性的5-HT4receptor受体拮抗剂 (pKb= 8.8)。GR 113808 的选择性是 5-HT1A，5-HT1B，5-HT2A，5-HT2C和 5-HT3受体的 300 倍。 |
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Gale, J.D., Grossman, C.J., Whitehead, J.W., et al.GR113808: A novel, selective antagonist with high affinity at the 5-HT4 receptorBr. J. Pharmacol.111(1),332-338(1994)
Van den Wyngaert, I., Gommeren, W., Verhasselt, P., et al.Cloning and expression of a human serotonin 5-HT4 receptor cDNAJ. Neurochem.69(5),1810-1819(1997)
