SKF-83566 hydrobromide
Cat. No.：YN320261
| 产品名称: | SKF-83566 hydrobromide |
| CAS No.: | 108179-91-5 |
| Chemical Name: | 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol, monohydrobromide |
| Synonyms: | SKF 83566 hydrobromide |
| 分子量: | 413.15 |
| 分子式: | C₁₇H₁₉Br₂NO |
| SMILES: | OC1=C(Br)C=C2CCN(C)CC(C3=CC=CC=C3)C2=C1.[H]Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SKF-83566 hydrobromide 是一种有效的，可通透血脑屏障的，具有口服活性的 D1 样多巴胺受体 (D1-like dopamine receptor) 拮抗剂，也可以作为一种较弱的竞争性拮抗剂作用于血管 5-HT2受体 (Ki= 11 nM)。SKF-83566 是一种竞争性多巴胺转运蛋白 (DAT) 抑制剂，IC50为 5.7 μM。在离体兔胸主动脉中，SKF-83566 对腺苷基环化酶 2 (AC2) 的选择性高于对 AC1和 AC5的。SKF-83566 可用于研究帕金森氏症和尼古 |
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Fritts, M.E., Mueller, K., and Morris, L.Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiridePharmacol. Biochem. Behav.60(3),639-644(1998)
Jacoby, S.M., and Currie, P.J.SKF 83566 attenuates the effects of ghrelin on performance in the object location memory taskNeurosci. Lett.504(3),316-320(2011)
Mittleman, G., Rosner, A.L., and Schaub, C.L.Polydipsia and dopamine: Behavioral effects of dopamine D1 and D2 receptor agonists and antagonistsJ. Pharmacol. Exp. Ther.271(2),638-650(1994)
