WAY-100635 Maleate
Cat. No.：YN320265
CAS No. ：1092679-51-0
| 产品名称: | WAY-100635 Maleate |
| CAS No.: | 1092679-51-0 |
| Chemical Name: | N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide, 2Z-butenedioate |
| Synonyms: | |
| 分子量: | 538.64 |
| 分子式: | C₂₉H₃₈N₄O₆ |
| SMILES: | O=C(O)/C=C\C(O)=O.O=C(N(C1=NC=CC=C1)CCN2CCN(CC2)C3=CC=CC=C3OC)C4CCCCC4.[1:1] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WAY-100635 maleate 是一种有效且具有选择性的5-hydroxytryptamine 1A (5-HT1A)受体拮抗剂，其IC50值为 0.91 nM，Ki值为 0.39 nM。WAY-100635 maleate 对于5-HT1A和 α1-肾上腺素的pIC50值分别为 8.9 和 6.6。WAY-100635 maleate 也是一种有效的多巴胺D4受体激动剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Zhuang, Z.P., Kung, M.P., and Kung, H.F.Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): A new iodinated 5-HT1A ligandJ. Med. Chem.37(10),1406-1407(1994)
Mensonides-Harsema, M.M., Liao, Y., Böttcher, H., et al.Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635J. Med. Chem.43(3),432-439(2000)
Forster, E.A., Cliffe, I.A., Bill, D.J., et al.A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635Eur. J. Pharmacol.281(1),81-88(1995)
Chemel, B.R., Roth, B.L., Armbruster, B., et al.WAY-100635 is a potent dopamine D4 receptor agonistPsychopharmacology (Berl)188(2),244-251(2006)
