Ketanserin tartrate
Cat. No.：YN320290
| 产品名称: | Ketanserin tartrate |
| CAS No.: | 83846-83-7 |
| Chemical Name: | 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione (2R,3R)-2,3-dihydroxybutanedioate |
| Synonyms: | R41468 tartrate |
| 分子量: | 545.51 |
| 分子式: | C₂₆H₂₈FN₃O₉ |
| SMILES: | O=C(C1=CC=CC=C1N2)N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C2=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ketanserin (R41468) tartrate 是一种选择性的5-HT2 receptor拮抗剂。Ketanserin tartrate 也抑制 hERG 电流 (IhERG)，IC50为 0.11 μM，这种作用具有浓度依赖性。 |
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Leysen, J.E., Awouters, F., Kennis, L., et al.Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptorsLife Sci.28(9),1015-1022(1981)
Van Neuten, J.M., Janssen, P.A.J., Van Beek, J., et al.Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptorsJ. Pharmacol. Exp. Ther.218(1),217-230(1981)
Du, W.-M., Miao, C.-Y., Liu, J.-G., et al.Effects of long-term treatment with ketanserin on blood pressure variability and end-organ damage in spontaneously hypertensive ratsJ. Cardiovasc. Pharmacol.41(2),233-239(2003)
Bijvank, S.W.N., Visser, Q., Duvekot, J.J., et al.Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trialEur. J. Obstet. Gynecol. Reprod. Biol.189,106-111(2015)
