SB-277011 hydrochloride
Cat. No.：YN320363
CAS No. ：215804-67-4
| 产品名称: | SB-277011 hydrochloride |
| CAS No.: | 215804-67-4 |
| Chemical Name: | N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Hydrochloride; SB 277011A Hydrochloride; SB 277211 Hydrochloride; |
| Synonyms: | SB-277011A hydrochloride |
| 分子量: | 475.02 |
| 分子式: | C₂₈H₃₁ClN₄O |
| SMILES: | O=C(C1=CC=NC2=CC=CC=C21)N[C@@H]3CC[C@H](CC3)CCN4CC5=C(CC4)C=C(C#N)C=C5.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-277011 hydrochloride (SB-277011A hydrochloride) 是一种强效、选择性、口服生物利用度和脑透多巴胺 D3受体(D3R) 拮抗剂，其Ki值在啮齿动物和人D3R 分别为 10.7 nM 和 11.2 nM。SB-277011 hydrochloride 对 D3 受体比其他多巴胺受体表现出 80-100 倍的选择性，，对 D3，D2，5-HT1B和 5-HT1D受体的pKi值分别为 8.0，6.0，<5.2 和 5.9。 |
| IC50和靶点: | [{name:"D3 Receptor:10.7-11.2 nM (Ki)'}, 'D2 Receptor', '5-HT1D Receptor', '5-HT1B Receptor'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
(1) Belliotti, T., et al.: Bioorg. Med. Chem. Lett., 7, 2403 (1997) & (2) Sokoloff, P., et al.: Nature. 347, 146 (1990) & (3) Reavill, C., et al.: J Pharmacol Exp Ther. 294, 1154 (2000)
