Risperidone
Cat. No.：YN320410
CAS No. ：106266-06-2
| 产品名称: | Risperidone |
| CAS No.: | 106266-06-2 |
| Chemical Name: | 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one |
| Synonyms: | 利培酮; R 64 766 |
| 分子量: | 410.48 |
| 分子式: | C₂₃H₂₇FN₄O₂ |
| SMILES: | O=C1C(CCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)=C(C)N=C5N1CCCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Risperidone是5-HT2受体的阻断剂，P-糖蛋白(P-Glycoprotein)的抑制剂 和dopamine D2受体的拮抗剂，其对 5-HT2A和 dopamine D2受体的Ki值分别为 4.8，5.9 nM。 |
| IC50和靶点: | [{name:"D2 Receptor:5.9 nM (Ki)"},{name: "5-HT2A Receptor:4.8 nM (Ki)'}, 'P-Glycoprotein'] |
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Leysen, J.E., Janssen, P.M., Gommeren, W., et al.In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidoneMol. Pharmacol.41(3),494-508(1992)
Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al.Radioreceptor binding profile of the atypical antipsychotic olanzapineNeuropsychopharmacology14(2),87-96(1996)
Rueter, L.E., Ballard, M.E., Gallagher, K.B., et al.Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophreniaPsychopharmacology (Berl.)176(3-4),312-319(2004)
