Syk Inhibitor II
Cat. No.：YN320455
CAS No. ：726695-51-8
| 产品名称: | Syk Inhibitor II |
| CAS No.: | 726695-51-8 |
| Chemical Name: | 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide |
| Synonyms: | |
| 分子量: | 340.30 |
| 分子式: | C₁₄H₁₅F₃N₆O |
| SMILES: | O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Syk Inhibitor II 是一种有效的，高选择性和 ATP 竞争性Syk抑制剂，IC50为 41 nM。Syk Inhibitor II 抑制 RBL 细胞释放5-HT，IC50为 460 nM。Syk Inhibitor II 对其他激酶的作用较小，并具有抗过敏作用。 |
| IC50和靶点: | [{name:"Syk:41 nM (IC50)"},{name: "serotonin:460 nM (IC50)"},{name: "PKCε:5.1 μM (IC50)"},{name: "PKCβ2:11 μM (IC50)"},{name: "ZAP-70:11.2 μM (IC50)"},{name: "Btk:15.5 μM (IC50)"},{name: "Itk:22.6 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hisamichi, J., Naito, R., Toyoshima, A., et al.Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivativesBioorg. Med. Chem.13(16),4936-4951(2005)
