Oxatomide
Cat. No.：YN320572
CAS No. ：60607-34-3
| 产品名称: | Oxatomide |
| CAS No.: | 60607-34-3 |
| Chemical Name: | 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one; |
| Synonyms: | |
| 分子量: | 426.55 |
| 分子式: | C₂₇H₃₀N₄O |
| SMILES: | O=C1NC2=CC=CC=C2N1CCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oxatomide 是一种有效的具有口服活性的双重 H1 组胺受体 (H1-histamine receptor) 和P2X7受体拮抗剂，具有抗组胺和抗过敏活性。Oxatomide 几乎完全阻断人P2X7受体中 ATP 诱导的电流 (IC50为 0.95 μM)。Oxatomide 可抑制 ATP 诱导的 Ca2+内流，IC50值为 0.43 μM，并且还抑制 5-羟色胺 (serotonin)。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Richards, D.M., et al.: Drugs, 27, 210 (1984),
