BRL 54443
Cat. No.：YN320708
| 产品名称: | BRL 54443 |
| CAS No.: | 57477-39-1 |
| Chemical Name: | 3-(1-methyl-4-piperidinyl)-1H-indol-5-ol |
| Synonyms: | BRL54443 |
| 分子量: | 230.31 |
| 分子式: | C₁₄H₁₈N₂O |
| SMILES: | OC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRL 54443 是5-HT1E/1F受体激动剂，Ki分别为 1.1 nM 和 0.7 nM，比对其它 5-HT 和多巴胺受体的抑制性高 30 倍以上。 |
| IC50和靶点: | [{name:"5-HT1E Receptor:1.1 nM (Ki)"},{name: "5-HT1F Receptor:0.7 nM (Ki)"},{name: "5-HT1A Receptor:63 nM (Ki)"},{name: "5-HT1B Receptor:126 nM (Ki)"},{name: "5-HT1D Receptor:63 nM (Ki)"},{name: "5-HT2A Receptor:1259 nM (Ki)"},{name: "5-HT2B Receptor:100 nM (Ki)"},{name: "5-HT2C Receptor:316 nM (Ki)"},{name: "5-HT6 Receptor:>10,000 nM (Ki)"},{name: "5-HT7 Receptor:>10,000 nM (Ki)"}] |
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Klein, M.T., Dukat, M., Glennon, R.A., et al.Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: A comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationshipsJ. Pharmacol. Exp. Ther.337(3),860-867(2011)
McKune, C.M., and Watts, S.W.Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway couplingJ. Pharmacol. Exp. Ther.297(1),88-95(2001)
Granados-Soto, V., Argüelles, C.F., Rocha-González, H.I., et al.The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in ratsNeuroscience165(2),561-568(2010)
