Brexpiprazole S-oxide
Cat. No.：YN320724
| 产品名称: | Brexpiprazole S-oxide |
| CAS No.: | 1191900-51-2 |
| Chemical Name: | DM-3411; 7-[4-[4-(1-Oxidobenzo[b]thien-4-yl)-1-piperazinyl]butoxy]-2(1H)-quinolinone; |
| Synonyms: | DM-3411 |
| 分子量: | 449.57 |
| 分子式: | C₂₅H₂₇N₃O₃S |
| SMILES: | O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5=O)C5=CC=C4)CC3)=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brexpiprazole S-oxide (DM-3411) 是 Brexpiprazole 的主要代谢产物，并通过细胞色素 P450 3A4 (CYP3A4) 代谢。Brexpiprazole 是一种非典型抗精神病药，是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为 0.12 nM 和 0.3 nM。Brexpiprazole 也是5-HT2A受体的拮抗剂，Ki为 0.47 nM。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:0.12 nM (Ki)"},{name: "5-HT2A Receptor:0.47 nM (Ki)"},{name: "D2 Receptor:0.3 nM (Ki)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)
