SB 242084 hydrochloride
Cat. No.：YN320733
| 产品名称: | SB 242084 hydrochloride |
| CAS No.: | 1049747-87-6 |
| Chemical Name: | 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide, dihydrochloride |
| Synonyms: | SB242084,SB 242084,CAS 1049747-87-6 |
| 分子量: | 467.78 |
| 分子式: | C₂₁H₂₁Cl₃N₄O₂ |
| SMILES: | O=C(N1CCC2=C1C=C(Cl)C(C)=C2)NC3=CC=C(OC4=CC=CN=C4C)N=C3.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB 242084盐酸盐是5-HT2C选择性抑制剂，pKi值9.0，对5-HT2A和5-HT2B作用弱100倍以上。 |
| IC50和靶点: | [{name:"5-HT2C Receptor:9.0 (pKi)"}] |
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Kennett, G.A., Wood, M.D., Bright, F., et al.SB 242084, a selective and brain penetrant 5-HT2C receptor antagonistNeuropharmacology36(4/5),609-620(1997)
Bromidge, S.M., Duckworth, M., Forbes, I.T., et al.6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline (SB-242084): The first selective and brain penetrant 5-HT2C receptor antagonistJ. Med. Chem.40(22),3494-3496(1997)
Fletcher, P.J., Tampakeras, M., Sinyard, J., et al.Characterizing the effects of 5-HT2C receptor ligands on motor activity and feeding behaviour in 5-HT2C receptor knockout miceNeuropharmacology57(3),259-267(2009)
Fletcher, P.J., Sinyard, J., and Higgins, G.A.The effects of the 5-HT2C receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonistsPsychopharmacology187(4),515-525(2006)
Dalton, G.L., Lee, M.D., Kennett, G.A., et al.Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mousePsychopharmacology185(1),45-47(2006)
