Prucalopride
Cat. No.：YN320824
CAS No. ：179474-81-8
| 产品名称: | Prucalopride |
| CAS No.: | 179474-81-8 |
| Chemical Name: | 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide |
| Synonyms: | 普芦卡必利 |
| 分子量: | 367.87 |
| 分子式: | C₁₈H₂₆ClN₃O₃ |
| SMILES: | ClC1=C(N)C(CCO2)=C2C(C(NC3CCN(CCCOC)CC3)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Prucalopride (R093877)是高亲和性5-HT4受体激动剂，对5-HT4a/4b的pKi分别为8.6/8.1，比对其它受体的亲和性高150倍。 |
| IC50和靶点: | [{name:"5-HT4A Receptor:8.6 (pKi)"},{name: "5-HT4B Receptor:8.1 (pKi)"}] |
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Briejer, M.R., Bosmans, J.P., Van Daele, P., et al.The in vitro pharmacological profile of prucalopride, a novel enterokinetic compoundEur. J. Pharmacol.423(1),71-83(2001)
Briejer, M.R., Prins, N.H., and Schuurkes, J.A.Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogsNeurogastroenterol. Motil.13(5),465-472(2001)
Johnson, D.E., Drummond, E., Grimwood, S., et al.The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillationsJ. Pharmacol. Exp. Ther.341(3),681-691(2012)
