Intepirdine
Cat. No.：YN320854
CAS No. ：607742-69-8
| 产品名称: | Intepirdine |
| CAS No.: | 607742-69-8 |
| Chemical Name: | 3-(phenylsulfonyl)-8-(1-piperazinyl)-quinoline |
| Synonyms: | SB-742457; GSK-742457; RVT-101 |
| 分子量: | 353.44 |
| 分子式: | C₁₉H₁₉N₃O₂S |
| SMILES: | O=S(C1=CC=CC=C1)(C2=CC(C=CC=C3N4CCNCC4)=C3N=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Intepirdine (SB742457) 是5-HT6受体拮抗剂，pKi为9.63，比对其它受体的抑制性高100倍以上。 |
| IC50和靶点: | [{name:"5-HT6 Receptor:9.63 (pKi)"}] |
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| Solvent & Solubility: |
Upton, N., Chuang, T.T., Hunter, A.J., et al.5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's diseaseNeurotherapeutics5(3),458-469(2008)
Grychowska, K., Satała, G., Kos, T., et al.Novel 1H-pyrrolo[3,2-c]quinoline based 5-HT6 receptor antagonists with potential application for the treatment of cognitive disorders associated with Alzheimer's diseaseACS Chem. Neurosci.7(7),972-983(2016)
Ivachtchenko, A.V., and Ivanekov, Y.A.Small molecule 5-HT6R Ligands: A comprehensive insight into their selectivity and activityCurr. Bioactive Compounds9(1),64-100(2013)
Higgs, S., Cooper, A.J., and Barnes, N.M.The 5-HT₂C receptor agonist, lorcaserin, and the 5-HT6 receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviourPsychopharmacology (Berl)233(3),417-424(2016)
