Latrepirdine dihydrochloride
Cat. No.：YN320874
CAS No. ：97657-92-6
| 产品名称: | Latrepirdine dihydrochloride |
| CAS No.: | 97657-92-6 |
| Chemical Name: | 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole, dihydrochloride |
| Synonyms: | Dimebolin dihydrochloride |
| 分子量: | 392.37 |
| 分子式: | C₂₁H₂₇Cl₂N₃ |
| SMILES: | CN(C1)CCC2=C1C3=CC(C)=CC=C3N2CCC4=CN=C(C)C=C4.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Latrepirdine dihydrochloride 是一种神经活性化合物，对组胺受体 (histaminergic receptor)，α-肾上腺素能受体 (α-adrenergic receptor) 和 5-羟色胺受体 (serotonergic receptor) 具有拮抗活性。Latrepirdine 刺激淀粉样前体蛋白 (APP) 分解代谢和 β-淀粉样蛋白 (amyloid-β,Aβ) 分泌。 |
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Wu, J., Li, Q., and Bezprozvanny, I.Evaluation of dimebon in cellular model of Huntington's diseaseMol. Neurodegener.3,15(2008)
Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al.Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channelsB. Exp. Biol. Med.132(5),1079-1083(2001)
Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al.Dimebon improves learning in animals with experimental Alzheimer's diseaseB. Exp. Biol. Med.129(6),640-642(2000)
Okun, I., Tkachenko, S.E., Khvat, A., et al.From anti-allergic to anti-Alzheimer's: Molecular pharmacology of DimebonTMCurr. Alzheimer Res.7(2),97-112(2010)
