Olanzapine
Cat. No.：YN320877
| 产品名称: | Olanzapine |
| CAS No.: | 132539-06-1 |
| Chemical Name: | 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine |
| Synonyms: | 奥氮平; LY170053 |
| 分子量: | 312.43 |
| 分子式: | C₁₇H₂₀N₄S |
| SMILES: | CC1=CC(C(N2CCN(C)CC2)=N3)=C(S1)NC4=C3C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Olanzapine (LY170053) 是一种选择性单胺能拮抗剂，高亲和力结合 5-羟色胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为 7、4、11、57 和 5 nM)，多巴胺D1-4(Ki=11-31 nM)，毒蕈碱M1-5(Ki=1.9-25 nM) 和肾上腺素α1受体 (Ki=19 nM)。Olanzapine 是一种非典型的抗精神病剂。 |
| IC50和靶点: | [{name:"5-HT2A Receptor:4 nM (Ki)"},{name: "5-HT1 Receptor:7 nM (Ki)"},{name: "5-HT6 Receptor:5 nM (Ki)"},{name: "5-HT2C Receptor:11 nM (Ki)"},{name: "5-HT3 Receptor:57 nM (Ki)"},{name: "Adrenergic α1 Receptor:19 nM (Ki)"},{name: "Muscarinic M1-5 Receptor:1.9-25 nM (Ki)'}, 'Dopamine Receptor', 'Mitophagy', 'Apoptosis'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al.Radioreceptor binding profile of the atypical antipsychotic olanzapineNeuropsychopharmacology14(2),87-96(1996)
Nowakowska, E., Kus, K., Ratajczak, P., et al.The influence of aripiprazole, olanzapine and enriched environment on depressant-like behavior, spatial memory dysfunction and hippocampal level of BDNF in prenatally stressed ratsPharmacol. Rep.66(3),404-411(2014)
Ashby, D.M., Lapish, C.C., and Phillips, A.G.Stability of avoidance behaviour following repeated intermittent treatment with clozapine, olanzapine or D,L-govadineBehav. Pharmacol.26(1-2),133-138(2015)
