Ziprasidone
Cat. No.：YN320879
| 产品名称: | Ziprasidone |
| CAS No.: | 146939-27-7 |
| Chemical Name: | 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one; 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-2-indolinone; 5-[2-[4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-on |
| Synonyms: | 齐拉西酮; CP-88059 |
| 分子量: | 412.94 |
| 分子式: | C₂₁H₂₁ClN₄OS |
| SMILES: | ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ziprasidone (CP-88059) 是一种抗精神病药物，是5-HT (serotonin)和多巴胺受体 (dopamine receptor) 拮抗剂。Ziprasidone 对大鼠 (Ki: 3.4 nM) 和人 (2.5 nM) 5-HT1A，5-HT2A (0.42 nM) 和 dopamine D2 (4.8 nM) 受体有很高的亲和力。Ziprasidone 是一种去甲肾上腺素再摄取 (norepinephrine reuptake) 抑制剂。 |
| IC50和靶点: | [{name:"Rat 5-HT1A Receptor:3.4 nM (Ki)"},{name: "human 5-HT1A Receptor:2.5 nM (Ki)"},{name: "Rat D2 Receptor:4.8 nM (Ki)"},{name: "Rat 5-HT2A:0.42 nM (Ki)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Kaddurah-Daouk, R. F., et al.: PCT Int. Appl. (2021), WO 2021016551 A1
