Sertindole
Cat. No.：YN320881
| 产品名称: | Sertindole |
| CAS No.: | 106516-24-9 |
| Chemical Name: | 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone |
| Synonyms: | 舍吲哚; Lu 23-174 |
| 分子量: | 440.94 |
| 分子式: | C₂₄H₂₆ClFN₄O |
| SMILES: | FC1=CC=C(N2C3=CC=C(Cl)C=C3C(C4CCN(CCN5CCNC5=O)CC4)=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sertindole是5-HT2A，5-HT2C，D2和αl受体拮抗剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1),29-39(2000)
Mørk, A., Witten, L.M., and Arnt, J.Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: A comparison with risperidone and exploration of mechanisms involvedPsychopharmacol. (Berl)206(1),39-49(2009)
Nikiforuk, A., and Popik, P.Effects of quetiapine and sertindole on subchronic ketamine-induced deficits in attentional set-shifting in ratsPsychopharmacol. (Berl)220(1),65-74(2012)
Idris, N., Neill, J., Grayson, B., et al.Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: Involvement of 5-HT6 and 5-HT 2A receptor mechanismsPsychopharmacol. (Berl)208(1),23-36(2010)
Carli, M., Calcagno, E., Mainini, E., et al.Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPPPsychopharmacol. (Berl)214(3),625-637(2011)
