Pimavanserin
Cat. No.：YN320888
CAS No. ：706779-91-1
| 产品名称: | Pimavanserin |
| CAS No.: | 706779-91-1 |
| Chemical Name: | N-[(4-fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]-urea |
| Synonyms: | 匹莫范色林; ACP-103 |
| 分子量: | 427.55 |
| 分子式: | C₂₅H₃₄FN₃O₂ |
| SMILES: | CC(C)COC1=CC=C(CNC(N(CC2=CC=C(F)C=C2)C3CCN(C)CC3)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pimavanserin是选择性的5-HT2A受体反向激动剂，pIC50和pKd分别为8.73 and 9.3。 |
| IC50和靶点: | [{name:"5-HT2A Receptor:8.7 (pIC50)"}] |
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| Solvent & Solubility: |
Vanover, K.E., Weiner, D.M., Makhay, M., et al.Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine2A receptor inverse agonistJ. Pharmacol. Exp. Ther.318(2),910-918(2006)
Gardell, L.R., Vanover, K.E., Pounds, L., et al.ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental modelsJ. Pharmacol. Exp. Ther.322(2),862-870(2007)
Goldman, J.G., and Holden, S.Treatment of psychosis and dementia in Parkinson's diseaseCurr. Treat. Options. Neurol.16(3),281(2014)
