Cariprazine
Cat. No.：YN320906
| 产品名称: | Cariprazine |
| CAS No.: | 839712-12-8 |
| Chemical Name: | N′-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethyl-urea |
| Synonyms: | 卡利拉嗪; RGH-188 |
| 分子量: | 427.41 |
| 分子式: | C₂₁H₃₂Cl₂N₄O |
| SMILES: | O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cariprazine是一种新型抗精神病候选药物，结合D3,D2和5-HT1A的Ki为0.085 nM，0.49 nM，2.6 nM。 |
| IC50和靶点: | [{name:"D2 Receptor:0.49 nM (Ki)"},{name: "D3 Receptor:0.085 nM (Ki)"},{name: "5-HT1A Receptor:2.6 nM (Ki)"}] |
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Mészáros, G.P., Agai-Csongor, E., and Kapás, M.Sensitive LC-MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urineJ. Pharm. Biomed. Anal.48(2),388-397(2008)
Kiss, B., Horváth, A., Némethy, Z., et al.Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist-partial agonist antipsychotic candidate: In vitro and neurochemical profileJ. Pharmacol. Exp. Ther.333(1),328-340(2010)
Gyertyán, I., Kiss, B., Sághy, K., et al.Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodentsNeurochem. Int.59(6),925-935(2011)
