Pardoprunox hydrochloride
Cat. No.：YN320937
| 产品名称: | Pardoprunox hydrochloride |
| CAS No.: | 269718-83-4 |
| Chemical Name: | 7-(4-methyl-1-piperazinyl)-2(3H)-benzoxazolone, monohydrochloride |
| Synonyms: | SLV-308 hydrochloride; DU-126891 hydrochloride |
| 分子量: | 269.73 |
| 分子式: | C₁₂H₁₆ClN₃O₂ |
| SMILES: | O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pardoprunox (SLV-308) hydrochloride 是多巴胺受体D2、D3部分激动剂和5-HT1A激动剂，pEC50分别为 8, 9.2, 6.3。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:6.3 (pEC50)"},{name: "D2 Receptor:8 (pEC50)"},{name: "D3 Receptor:9.2 (pEC50)"}] |
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Glennon, J.C., Van Scharrenburg, G., Ronken, E., et al.In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): A novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonistSynapse60(8),599-608(2006)
Jones, C.A., Johnston, L.C., Jackson, M.J., et al.An in vivo pharmacological evaluation of pardoprunox (SLV308)—A novel combined dopamine D2/D3 receptor partial agonist and 5-HT1A receptor agonist with efficacy in experimental models of Parkinson's diseaseEur. Neuropsychopharmacol.20(8),582-593(2010)
Rascol, O., Brozova, J., Hauser, R.A., et al.Pardoprunox as adjunct therapy to levodopa in patients with Parkinson's disease experiencing motor fluctuations: Results of a double-blind, randomized, placebo-controlled, trialParkinsonism Relat. Disord.18(4),370-376(2012)
