Vortioxetine
Cat. No.：YN320978
CAS No. ：508233-74-7
| 产品名称: | Vortioxetine |
| CAS No.: | 508233-74-7 |
| Chemical Name: | 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-piperazine |
| Synonyms: | 沃替西汀; Lu AA 21004 |
| 分子量: | 298.45 |
| 分子式: | C₁₈H₂₂N₂S |
| SMILES: | CC1=CC=C(SC2=CC=CC=C2N3CCNCC3)C(C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vortioxetine 是5-HT1A，5-HT1B，5-HT3A，5-HT7受体 和 5-羟色胺转运体(SERT)的抑制剂，其Ki值分别为 15 nM，33 nM，3.7 nM，19 nM 和 1.6 nM。 |
| IC50和靶点: | [{name:"sPLA2:15 nM (Ki)"},{name: "5-HT3A Receptor:3.7 nM (Ki)"},{name: "Human 5-HT7 Receptor:19 nM (Ki)"},{name: "SERT:1.6 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bang-Andersen, B., Ruhland, T., Jørgensen, M., et al.Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A novel multimodal compound for the treatment of major depressive disorderJ. Med. Chem.54(9),3206-3221(2011)
Guilloux, J.P., Mendez-David, I., Pehrson, A., et al.Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in miceNeuropharmacology73,147-159(2013)
