Vortioxetine D8
Cat. No.：YN320980
| 产品名称: | Vortioxetine D8 |
| CAS No.: | 2140316-62-5 |
| Chemical Name: | 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine-2,2,3,3,5,5,6,6-d8 |
| Synonyms: | Lu AA 21004 D8 |
| 分子量: | 306.49 |
| 分子式: | C₁₈H₁₄D₈N₂S |
| SMILES: | CC1=CC=C(SC2=CC=CC=C2N3C([2H])([2H])C([2H])([2H])NC([2H])([2H])C3([2H])[2H])C(C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vortioxetine D8 是氘代标记的Vortioxetine。Vortioxetine 是5-HT1A，5-HT1B，5-HT3A，5-HT7受体 和 5-羟色胺转运体(SERT)的抑制剂，其Ki值分别为 15 nM，33 nM，3.7 nM，19 nM 和 1.6 nM。 |
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Bang-Andersen, B., Ruhland, T., Jørgensen, M., et al.Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A novel multimodal compound for the treatment of major depressive disorderJ. Med. Chem.54(9),3206-3221(2011)
Guilloux, J.P., Mendez-David, I., Pehrson, A., et al.Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in miceNeuropharmacology73,147-159(2013)
