PRX-08066
Cat. No.：YN320994
CAS No. ：866206-54-4
| 产品名称: | PRX-08066 |
| CAS No.: | 866206-54-4 |
| Chemical Name: | 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile |
| Synonyms: | PRX08066,PRX 08066 |
| 分子量: | 401.89 |
| 分子式: | C₁₉H₁₇ClFN₅S |
| SMILES: | N#CC1=CC(CN2CCC(NC3=C(C=C(Cl)S4)C4=NC=N3)CC2)=CC=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PRX-08066是5-HT受体2B（5-HT2BR）拮抗剂，IC50为3.4 nM，能选择性的促使肺动脉血管舒张。 |
| IC50和靶点: | [{name:"5-HT2B Receptor:3.4 nM (IC50)"}] |
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| Solvent & Solubility: |
Porvasnik, S.L., Germain, S., Embury, J., et al.PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in ratsJ. Pharmacol. Exp. Ther.334(2),364-372(2010)
