Piboserod
Cat. No.：YN321008
| 产品名称: | Piboserod |
| CAS No.: | 152811-62-6 |
| Chemical Name: | N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide |
| Synonyms: | SB-207266 |
| 分子量: | 369.50 |
| 分子式: | C₂₂H₃₁N₃O₂ |
| SMILES: | O=C(C1=C(OCCC2)N2C3=C1C=CC=C3)NCC4CCN(CCCC)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Piboserod (SB 207266)是5-羟色胺受体5-HT4选择性抑制剂。 |
| IC50和靶点: | |
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Wardle, K.A., Bingham, S., Ellis, E.S., et al.Selective and functional 5-hydroxytryptamine4 receptor antagonism by SB 207266Br. J. Pharmacol.118(3),665-670(1996)
Claeysen, S., Sebben, M., Bécamel, C., et al.Pharmacological properties of 5-Hydroxytryptamine4 receptor antagonists on constitutively active wild-type and mutated receptorsMol. Pharmacol.58(1),136-144(2000)
Claeysen, S., Sebben, M., Bécamel, C., et al.Pharmacological properties of 5-Hydroxytryptamine4 receptor antagonists on constitutively active wild-type and mutated receptorsMol. Pharmacol.58(1),136-144(2000)
Sanger, G.J., Yoshida, M., Yahyah, M., et al.Increased defecation during stress or after 5-hydroxytryptophan: Selective inhibition by the 5-HT(4) receptor antagonist, SB-207266Br. J. Pharmacol.130(3),706-712(2000)
Ellis, M., Chambers, J.D., Gwynne, R.M., et al.Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestineAm. J. Physiol. Gastrointest. Liver Physiol.304(8),G749-G761(2013)
Birkeland, J.A.K., Sjaastad, I., Brattelid, T., et al.Effects of treatment with a 5-HT4 receptor antagonist in heart failureBr. J. Pharmacol.150(2),143-152(2007)
