8-Hydroxy-DPAT hydrobromide
Cat. No.：YN321015
CAS No. ：76135-31-4
| 产品名称: | 8-Hydroxy-DPAT hydrobromide |
| CAS No.: | 76135-31-4 |
| Chemical Name: | 7-(dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol, monohydrobromide |
| Synonyms: | 8-OH-DPAT hydrobromide |
| 分子量: | 328.29 |
| 分子式: | C₁₆H₂₆BrNO |
| SMILES: | [H]Br.CCCN(CCC)C(CCC1=CC=C2)CC1=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) 是一种有效的，选择性5-HT1A激动剂，pIC50为 8.19。8-Hydroxy-DPAT hydrobromide 对 5-HT1结合位点的亚型具有近 1000 倍的选择性。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:8.19 (pIC50)"}] |
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Meller, E., Li, H., Carr, K.D., et al.5-hydroxytryptamine1A receptor-stimulated [35S]GTPγS binding in rat brain: Absence of regional differences in coupling efficiencyJ. Pharmacol. Exp. Ther.292(2),684-691(2000)
Schmitz, D.A., Gloveli, T., Empson, R.M., et al.Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanismJ. Physiol.508(Pt 1),119-129(1998)
McMahon, L.R.Enhanced discriminative stimulus effects of Δ9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeysDrug Alcohol Depend.165,87-93(2016)
Takahashi, A., Shimamoto, A., Boyson, C.O., et al.GABAB receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in miceJ. Neurosci.30(35),11771-11780(2010)
Stiedl, O., Misane, I., Spiess, J., et al.Involvement of the 5-HT1A receptors in classical fear conditioning in C57BL/6J miceJ. Neurosci.20922),8515-8527(2000)
Abdala, A.P.L., Dutschmann, M., Bissonnette, J.M., et al.Correction of respiratory disorders in a mouse model of Rett syndromeProc. Natl. Acad. Sci. USA107(42),18208-18213(2010)
Restrepo, B., Martín, M.L., San Román, L., et al.Peripheral 5-HT1A and 5-HT7 serotonergic receptors modulate parasympathetic neurotransmission in long-term diabetic ratsExp. Diabetes Res.,686734(2010)
