cis-(Z)-Flupentixol dihydrochloride
Cat. No.：YN321040
| 产品名称: | cis-(Z)-Flupentixol dihydrochloride |
| CAS No.: | 51529-01-2 |
| Chemical Name: | 4-[3-[(3Z)-2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol, dihydrochloride |
| Synonyms: | cis-(Z)-Flupenthixol dihydrochloride |
| 分子量: | 507.44 |
| 分子式: | C₂₃H₂₇Cl₂F₃N₂OS |
| SMILES: | OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | cis-(Z)-Flupentixol dihydrochloride 是有效、选择性的多巴胺DA D1/D2受体的拮抗剂，其对D2 受体和5-HT2A的Ki值分别为 0.38 nM 和 7 nM。 |
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Seeman, P.Atypical antipsychotics: Mechanism of actionCan. J. Psychiatry47(1),27-38(2002)
Wenzel, J.M., Su, Z.I., Shelton, K., et al.The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in ratsPharmacol. Biochem. Behav.114-115,90-96(2013)
Kornhuber, J., Muehlbacher, M., Trapp, S., et al.Identification of novel functional inhibitors of acid sphingomyelinasePLoS One6(8),1-13(2011)
