Iloperidone
Cat. No.：YN321132
CAS No. ：133454-47-4
| 产品名称: | Iloperidone |
| CAS No.: | 133454-47-4 |
| Chemical Name: | 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-ethanone |
| Synonyms: | 伊潘立酮; HP 873 |
| 分子量: | 426.48 |
| 分子式: | C₂₄H₂₇FN₂O₄ |
| SMILES: | CC(C1=CC=C(OCCCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)C(OC)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Iloperidone (HP 873) 是一种D2/5-HT2受体拮抗剂，可作用于精神分裂症的非典型抗精神病药。 |
| IC50和靶点: | [{name:"Rat D2 Receptor:54 nM (Ki)"},{name: "Rat 5-HT2 Receptor:3.1 nM (Ki)"},{name: "Rat D1 Receptor:546 nM (Ki)"},{name: "Rat 5-HT1A Receptor:168 nM (Ki)"},{name: "Rat 5-HT6 Receptor:42.7 μM (Ki)"},{name: "Rat 5-HT7 Receptor:21.6 nM (Ki)"},{name: "Human D1 Receptor:216 nM (Ki)"},{name: "Human D3 Receptor:7.1 nM (Ki)"},{name: "Human D4 Receptor:25 nM (Ki)"},{name: "Human D5 Receptor:319 nM (Ki)"},{name: "Human 5-HT2A Receptor:5.6 nM (Ki)"},{name: "Human 5-HT2C Receptor:42.8 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Barr, A.M., Powell, S.B., Markou, A., et al.Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in ratsNeuropharmacology51(3),457-465(2006)
Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1),29-39(2000)
Kongsamut, S., Roehr, J.E., Cai, J., et al.Iloperidone binding to human and rat dopamine and 5-HT receptorsEur. J. Pharmacol.317(2-3),417-423(1996)
Szewczak, M.R., Corbett, R., Rush, D.K., et al.The pharmacological profile of iloperidone, a novel atypical antipsychotic agentJ. Pharmacol. Exp. Ther.274(3),1404-1413(1995)
