PF-04995274
Cat. No.：YN321177
CAS No. ：1331782-27-4
| 产品名称: | PF-04995274 |
| CAS No.: | 1331782-27-4 |
| Chemical Name: | tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-2H-pyran-4-ol |
| Synonyms: | PF-4995274 |
| 分子量: | 432.51 |
| 分子式: | C₂₃H₃₂N₂O₆ |
| SMILES: | OC1(CN2CCC(COC3=NOC4=CC=CC(O[C@H]5COCC5)=C34)CC2)CCOCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-04995274 是一种强效，高亲和力，口服活性血清素 4 受体 (5-HT4R) 的部分激动剂。PF-04995274 对人5-HT4A/4B/4D/4E的EC50范围为 0.26-0.47 nM (Ki范围为 0.15-0.46 nM)，对大鼠5-HT4S/4L/4E的EC50范围为 0.59-0.65 nM (大鼠5-HT4S的Ki为 0.30 nM)。PF-04995274 是脑渗透的，可用于与阿尔茨海默症相关的认知障碍的研究。 |
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Brodney, M.A., Johnson, D.E., Sawant-Basak, A., et al.Identification of multiple 5‑HT4 partial agonist clinical candidates for the treatment of alzheimer’s diseaseJ. Med. Chem.55(21),9240-9254(2012)
