Ipsapirone
Cat. No.：YN321238
| 产品名称: | Ipsapirone |
| CAS No.: | 95847-70-4 |
| Chemical Name: | 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one, 1,1-dioxide |
| Synonyms: | TVX Q 7821 free base |
| 分子量: | 401.48 |
| 分子式: | C₁₉H₂₃N₅O₃S |
| SMILES: | O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=NC=CC=N4)CC3)S2(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ipsapirone (TVX Q 7821)，是具有抗焦虑活性的化合物，是5-HT1A受体的部分激动剂，也表现出5-HT1A受体的拮抗作用，并且只在高剂量时，对 5-HT2和α1肾上腺素能表现出抑制作用。 |
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Glaser, T., and Traber, J.Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sitesNaunyn Schmiedebergs Arch. Pharmacol.329(3),211-215(1985)
Sharp, T., Bramwell, S.R., and Grahame-Smith, D.G.5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysisBr. J. Pharmacol.96(2),283-290(1989)
Ichikawa, J., and Meltzer, H.Y.The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbensBrain Res.842(2),445-451(1999)
Traber, J., Davies, M.A., Dompert, W.U., et al.Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821Brain Res. Bull.12(6),741-744(1984)
Rausch, J.L., Johnson, M.E., Kasik, K.E., et al.Temperature regulation in depression: Functional 5HT1A receptor adaptation differentiates antidepressant responseNeuropsychopharmacology31(10),2274-2280(2006)
