Lumateperone tosylate
Cat. No.：YN321242
| 产品名称: | Lumateperone tosylate |
| CAS No.: | 1187020-80-9 |
| Chemical Name: | 1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one 4-methylbenzenesulfonic acid |
| Synonyms: | ITI-007 tosylate |
| 分子量: | 565.70 |
| 分子式: | C₃₁H₃₆FN₃O₄S |
| SMILES: | O=C(C1=CC=C(F)C=C1)CCCN2CC[C@@](N3CCN(C)C4=C3C5=CC=C4)([H])[C@@]5([H])C2.O=S(C6=CC=C(C)C=C6)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lumateperone tosylate (ITI-007 tosylate) 是5-HT 2A受体拮抗剂 (KI= 0.54 nM), 突触前D2受体的部分激动剂和突触后D2受体的拮抗剂 (KI= 32 nM)。 |
| IC50和靶点: | [{name:"5-HT2A Receptor:0.54 nM (Ki)"}] |
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| Solvent & Solubility: |
Li, P., Zhang, Q., Robichaud, A.J., et al.Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disordersJ. Med. Chem.57(6),2670-2682(2014)
