Alosetron Hydrochloride
Cat. No.：YN321297
CAS No. ：122852-69-1
| 产品名称: | Alosetron Hydrochloride |
| CAS No.: | 122852-69-1 |
| Chemical Name: | 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, monohydrochloride |
| Synonyms: | GR 68755C; GR 68755 Hydrochloride; GR 68755X Hydrochloride |
| 分子量: | 330.81 |
| 分子式: | C₁₇H₁₉ClN₄O |
| SMILES: | O=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alosetron Hydrochloride (GR 68755C) 是一种高效、高选择性的 5-HT3 受体 (5-HT3 receptor) 拮抗剂。Alosetron Hydrochloride 用于肠易激综合征 (IBS) 的研究。Alosetron Hydrochloride 阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化，IC50在 ~55 nM。Alosetron Hydrochloride 减轻清醒或麻醉犬直肠扩张的内脏伤害性效应。具有抗炎活性。 |
| IC50和靶点: | |
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Humphrey, P.P., Bountra, C., Clayton, N., et al.Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndromeAilment Pharmacol. Ther.13(Suppl 2),31-38(1999)
Kilpatrick, G.J., Hagan, R.M., Butler, A., et al.GR68755, a potent and selective antagonist of 5-HT3 receptorsGlaxo Grp. Res. Ltd.,259P(1991)
Taquichi, R., Shilkata, K., Furuya, Y., et al.Selective corticotropin-releasing factor 1 receptor antagonist E2508 reduces restraint stress-induced defecation and visceral pain in rat modelsPsychoneuroendocrinology75,110-115(2017)
