Rotigotine
Cat. No.：YN321304
CAS No. ：99755-59-6
| 产品名称: | Rotigotine |
| CAS No.: | 99755-59-6 |
| Chemical Name: | (6S)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol |
| Synonyms: | 罗替戈汀; N-0437; N-0923 |
| 分子量: | 315.47 |
| 分子式: | C₁₉H₂₅NOS |
| SMILES: | CCCN(CCC1=CC=CS1)[C@H]2CCC3=C(C=CC=C3O)C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rotigotine (N-0437; N-0923) 是dopamine receptor激动剂，是5-HT1A receptor的部分激动剂，以及α2B-adrenergic receptor的拮抗剂，Ki值分别为 0.71 nM (dopamine D3 receptor)，4-15 nM (D2，D5，D4 receptors)，83 nM (dopamine D1 receptor)。 |
| IC50和靶点: | [{name:"D3 Receptor:0.71 nM (Ki)"},{name: "D2 Receptor:4-15 nM (Ki)"},{name: "D5 Receptor:4-15 nM (Ki)"},{name: "D4 Receptor:4-15 nM (Ki)"},{name: "D1 Receptor:83 nM (Ki)"},{name: "5-HT1A Receptor:30 nM (Ki)"},{name: "5-HT7 Receptor:86 nM (Ki)"}] |
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| Solvent & Solubility: |
Wood, M., Dubois, V., Scheller, D., et al.Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptorsBr. J. Pharmacol.172(4),1124-1135(2015)
