Rotigotine Hydrochloride
Cat. No.：YN321319
CAS No. ：125572-93-2
| 产品名称: | Rotigotine Hydrochloride |
| CAS No.: | 125572-93-2 |
| Chemical Name: | (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride Salt; (-)-N 0437 Hydrochloride Salt; N 0923 Hydrochloride Salt; Neupro Hydrochloride Salt; SPM 962 Hydrochloride Salt; Rotigotine Hydrochloride; |
| Synonyms: | 罗替戈汀盐酸盐; N-0923 Hydrochloride |
| 分子量: | 351.93 |
| 分子式: | C₁₉H₂₆ClNOS |
| SMILES: | OC1=C2CC[C@@H](CC2=CC=C1)N(CCC3=CC=CS3)CCC.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rotigotine Hydrochloride (N-0923 Hydrochloride) 是dopamine receptor纯激动剂，是5-HT1A receptor的部分激动剂，以及α2B-adrenergic receptor的拮抗剂，Ki值分别为 0.71 nM (dopamine D3 receptor)，4-15 nM (D2，D5，D4 receptors)，83 nM (dopamine D1 receptor)。 |
| IC50和靶点: | [{name:"D3 Receptor:0.71 nM (Ki)"},{name: "D2 Receptor:4-15 nM (Ki)"},{name: "D5 Receptor:4-15 nM (Ki)"},{name: "D4 Receptor:4-15 nM (Ki)"},{name: "D1 Receptor:83 nM (Ki)"},{name: "α1A:176 nM (Ki)"},{name: "α1B:273 nM (Ki)"},{name: "α2A:338 nM (Ki)"},{name: "α2B:27 nM (Ki)"},{name: "5-HT1A Receptor:30 nM (Ki)"},{name: "5-HT7 Receptor:86 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989),
