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Talipexole dihydrochloride

Cat. No.:YN321320

  • CAS No. :36085-73-1

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    • 参考文献
    • 产品名称: Talipexole dihydrochloride
      CAS No.: 36085-73-1
      Chemical Name: 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d]azepin-2-amine, dihydrochloride
      Synonyms:B-HT 920 dihydrochloride
      分子量:282.23
      分子式:C₁₀H₁₇Cl₂N₃S
      SMILES:NC1=NC2=C(CCN(CC2)CC=C)S1.Cl.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Talipexole dihydrochloride (B-HT 920 dihydrochloride) 是多巴胺D2受体和α2-肾上腺素受体激动剂,5-HT3受体拮抗剂,有抗帕金森病活性。
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    • Maina, F.K., and Mathews, T.A.A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatumACS Chem Neurosci.1(6),450-462(2010)

      Mewshaw, R.E., Kavanagh, J.J., Stack, G., et al.New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromansJ. Med. Chem.40(26),4235-4256(1997)

      Robertson, G.S., Tham, C.S., Wilson, C., et al.In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine releaseJ. Pharmacol. Exp. Ther.264(3),1344-1351(1993)

      Kitamura, Y.Dopaminergic neuroprotection and reconstruction of neural network tiaraYakugaku Zasshi130(10),1263-1272(2010)

      Nishio, H., Kohno, Y., Fujii, A., et al.5-HT3 receptor blocking properties of the antiparkinsonian agent, talipexoleGen. Pharmcol.27(5),778-785(1996)

      Rocco, D., and Taira, C.A.Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated ratsGen. Pharmcol.32(1),29-34(1999)

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