Paliperidone
Cat. No.：YN321329
CAS No. ：144598-75-4
| 产品名称: | Paliperidone |
| CAS No.: | 144598-75-4 |
| Chemical Name: | 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one |
| Synonyms: | 9-羟基利培酮; 9-Hydroxyrisperidone |
| 分子量: | 426.48 |
| 分子式: | C₂₃H₂₇FN₄O₃ |
| SMILES: | CC1=C(C(N2CCCC(C2=N1)O)=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(F)=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Paliperidone (9-Hydroxyrisperidone) 是 Risperidone 的主要活性代谢产物，是多巴胺 D2 (dopamine D2) 拮抗剂和5-HT2A拮抗剂。Paliperidone 对α1和α2肾上腺素能受体和H1组胺能受体也有拮抗作用。Paliperidone 是一种抗精神病药物，对精神分裂症有效。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
MacDowell, K.S., Munarriz-Cuezva, E., Caso, J.R., et al.Paliperidone reverts Toll-like receptor 3 signaling pathway activation and cognitive deficits in a maternal immune activation mouse model of schizophreniaNeuropharmacology116,196-207(2017)
Burstein, E.S., Ma, J., Wong, S., et al.Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonistJ. Pharmacol. Exp. Ther.315(3),1278-1287(2005)
Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1),29-39(2000)
