Perphenazine
Cat. No.：YN321345
| 产品名称: | Perphenazine |
| CAS No.: | 58-39-9 |
| Chemical Name: | 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol |
| Synonyms: | 奋乃静 |
| 分子量: | 403.97 |
| 分子式: | C₂₁H₂₆ClN₃OS |
| SMILES: | OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Perphenazine 是一个经典的抗精神病药物，能够抑制5-HT2A受体，α1A肾上腺素能受体，多巴胺D2/D3、D2L受体, 以及 组胺H1受体，对应的 Ki值分别为5.6，10，0.765/0.13，3.4 和8 nM。 |
| IC50和靶点: | [{name:"D2 Receptor:0.56 nM (Ki)"},{name: "D3 Receptor:0.43 nM (Ki)"},{name: "D4 Receptor:28.5 nM (Ki)"},{name: "5-HT2A Receptor:5.6 nM (Ki)"},{name: "5-HT6 Receptor:17 nM (Ki)"},{name: "5-HT7 Receptor:23 nM (Ki)"},{name: "H2 Receptor:132 nM (Ki)"},{name: "5-HT1A Receptor:421 nM (Ki)"}] |
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Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3),519-526(2003)
Ozdemir, E., Bagcivan, I., and Gursoy, S.Role of D₁/D₂ dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in ratsBosn. J. Basic Med. Sci.13(2),119-125(2013)
Carter, D.B., Kennett, M.J., and Franklin, C.L.Use of perphenazine to control cannibalism in DBA/1 miceComp. Med.52(5),452-455(2002)
