Flibanserin
Cat. No.：YN321349
CAS No. ：167933-07-5
| 产品名称: | Flibanserin |
| CAS No.: | 167933-07-5 |
| Chemical Name: | 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one |
| Synonyms: | 氟立班丝氨; BIMT-17; BIMT-17BS |
| 分子量: | 390.40 |
| 分子式: | C₂₀H₂₁F₃N₄O |
| SMILES: | O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Flibanserin (BIMT-17) 是 5-羟色胺(5-HT1A)受体 (Ki=1 nM) 的完全激动剂和5-HT2A拮抗剂 (49 nM)。Flibanserin 与多巴胺 D4 受体 (Ki=4-24 nM) 结合，对多种其他神经递质受体和离子通道的亲和力可忽略不计。Flibanserin 有潜力用于性欲减退 (HSDD)的研究。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:1 nM (Ki)"},{name: "5-HT2A Receptor:49 nM (Ki)"},{name: "dopamine D4 receptors:4-24 nM (Ki)"}] |
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Invernizzi, R.W., Sacchetti, G., Parini, S., et al.Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: Role of 5-HT1A receptorsBr. J. Pharmacol.139(7),1281-1288(2003)
Stahl, S.M.Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorderCNS Spectr.20(1),(2015)
