Tropisetron Hydrochloride
Cat. No.：YN321372
CAS No. ：105826-92-4
| 产品名称: | Tropisetron Hydrochloride |
| CAS No.: | 105826-92-4 |
| Chemical Name: | 1H-indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, monohydrochloride |
| Synonyms: | 盐酸托烷司琼; SDZ-ICS-930 |
| 分子量: | 320.81 |
| 分子式: | C₁₇H₂₁ClN₂O₂ |
| SMILES: | O=C(C1=CNC2=C1C=CC=C2)O[C@H]3C[C@H]4CC[C@H](N4C)C3.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tropisetron Hydrochloride (SDZ-ICS-930) 是5-HT3受体拮抗剂和α7-烟碱受体激动剂，对5-HT3受体的IC50为70.1 nM。 |
| IC50和靶点: | [{name:"5-HT3 Receptor:70.1 nM (IC50)"}] |
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| Solvent & Solubility: |
Schiavi, G.B., Brunet, S., Rizzi, C.A., et al.Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand bindingNeuropharmacology33(3-4),543-549(1994)
Rothlin, C.V., Katz, E., Verbitsky, M., et al.The α9 nicotinic acetylcholine receptor shares pharmacological properties with type A γ-aminobutyric acid, glycine, and type 3 serotonin receptorsMol. Pharmacol.55(2),248-254(1999)
Macor, J.E., Gurley, D., Lanthorn, T., et al.The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonistBioorg. Med. Chem. Lett.11(3),319-321(2001)
Supplisson, S., and Chesnoy-Marchais, D.Glycine receptor β subunits play a critical role in potentiation of glycine responses by ICS-205,930Mol. Pharmacol.58(4),763-770(2000)
Round, A., and Wallis, D.I.The depolarizing action of 5-hydroxytryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930Br. J. Pharmacol.88(2),485-494(1986)
Watson, J.W., Gonsalves, S.F., Fossa, A.A., et al.The anti-emetic effects of CP-99,994 in the ferret and the dog: Role of the NK1 receptorBr. J. Pharmacol.115(1),84-94(1995)
