Quetiapine hemifumarate
Cat. No.：YN321373
| 产品名称: | Quetiapine hemifumarate |
| CAS No.: | 111974-72-2 |
| Chemical Name: | 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol, 2E-butenedioate (2:1) |
| Synonyms: | 富马酸奎硫平 |
| 分子量: | 441.54 |
| 分子式: | C₂₃H₂₇N₃O₄S |
| SMILES: | OCCOCCN(CC1)CCN1C2=NC(C=CC=C3)=C3SC4=C2C=CC=C4.O=C(O)/C=C/C(O)=O.[0.5] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Quetiapine hemifumarate 是一种5-HT受体激动剂，对人5-HT1A的pEC50值为 4.77。Quetiapine hemifumarate 是多巴胺受体 (dopamine receptor) 拮抗剂，对人D2的pIC50值为 6.33。Quetiapine hemifumarate 对人D2，HT1A，5-HT2A，5-HT2C受体具有中高等亲和力，pKi值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。 |
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Klein, L., Bangh, S., and Cole, J.B.Intentional recreational abuse of quetiapine compared to other second-generation antipsychoticsWest. J. Emerg. Med.18(2),243-250(2017)
Kim, S., Lee, G., Kim, E., et al.Quetiapine misuse and abuse: Is it an atypical paradigm of drug seeking behaviorJ. Res. Pharm. Pract.6(1),12-15(2017)
