Lurasidone
Cat. No.：YN321377
CAS No. ：367514-87-2
| 产品名称: | Lurasidone |
| CAS No.: | 367514-87-2 |
| Chemical Name: | (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione |
| Synonyms: | 鲁拉西酮; SM-13496 |
| 分子量: | 492.68 |
| 分子式: | C₂₈H₃₆N₄O₂S |
| SMILES: | O=C([C@H]1[C@H]2C[C@H](CC2)[C@@H]31)N(C[C@H](CCCC4)[C@@H]4CN5CCN(CC5)C6=NSC7=CC=CC=C67)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lurasidone (SM-13496) 是dopamine D2和5-HT7的拮抗剂，IC50值分别为 1.68 和 0.495 nM。 Lurasidone (SM-13496) 也是5-HT1A受体的部分激动剂，IC50值为 6.75 nM。 |
| IC50和靶点: | [{name:"5-HT7 Receptor:0.495 nM (IC50)"},{name: "5-HT1A Receptor:6.75 nM (IC50)"},{name: "D2 Receptor:1.68 nM (IC50)"}] |
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Ishiyama, T., Tokuda, K., Ishibashi, T., et al.Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance testEur. J. Pharmacol.572(2-3),160-170(2007)
Enomoto, T., Ishibashi, T., Tokuda, K., et al.Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in ratsBehav. Brain Res.186(2),197-207(2008)
Cates, L.N., Roberts, A.J., Huitron-Resendiz, S., et al.Effects of lurasidone in behavioral models of depression. Role of the 5-HT7 receptor subtypeNeuropharmacology70,211-217(2013)
