Granisetron Hydrochloride
Cat. No.：YN321381
| 产品名称: | Granisetron Hydrochloride |
| CAS No.: | 107007-99-8 |
| Chemical Name: | 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide, monohydrochloride |
| Synonyms: | 盐酸格拉司琼; BRL 43694A |
| 分子量: | 348.87 |
| 分子式: | C₁₈H₂₅ClN₄O |
| SMILES: | CN1N=C(C(N[C@H]2C[C@H](N3C)CCC[C@H]3C2)=O)C4=CC=CC=C41.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Granisetron(BRL 43694A)盐酸盐是5-HT3受体拮抗剂，可作为化疗后止吐剂。 |
| IC50和靶点: | [{name:"5-HT3 Receptor:17 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
López-Rodríguez, M.L., Benhamú, B., Morcillo, M.J., et al.Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptorsJ. Med. Chem.42(24),5020-5028(1999)
Haga, K., Inaba, K., Shoji, H., et al.The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesisJpn. J. Pharmacol.63(3),377-383(1993)
