Mirtazapine
Cat. No.：YN321455
| 产品名称: | Mirtazapine |
| CAS No.: | 85650-52-8 |
| Chemical Name: | 1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine |
| Synonyms: | 米氮平; Org3770; 6-Azamianserin |
| 分子量: | 265.35 |
| 分子式: | C₁₇H₁₉N₃ |
| SMILES: | CN1CC2C3=CC=CC=C3CC4=CC=CN=C4N2CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mirtazapine (Org3770) 是一种有效的具有口服活性的去甲肾上腺素能和特异性血清素能抗抑郁剂 (NaSSA)。Mirtazapine 也是一种5-HT2、5-HT3，组胺 H1 受体 (histamine H1 receptor) 和 α2-肾上腺素受体 (α2-adrenoceptor) 拮抗剂，pKi值分别为 8.05、8.1、9.3 和 6.95。 |
| IC50和靶点: | [{name:"5-HT3 Receptor:8.1 (pKi)"},{name: "5-HT2 Receptor:8.05 (pKi)"},{name: "H1 Receptor:9.3 (pKi)"},{name: "α2-adrenergic receptor:6.95 (pKi)"}] |
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Voigt, R.M., Mickiewicz, A.L., and Napier, T.C.Repeated mirtazapine nullifies the maintenance of previously established methamphetamine-induced conditioned place preference in ratsBehav. Brain Res.225(1),91-96(2011)
Barbosa-Méndez, S., Matus-Ortega, M., Jacinto-Gutiérrez, S., et al.Mirtazapine impairs acquisition and reinstatement of cocaine-induced place preference in ratsEur. J. Pharmacol.820,183-190(2018)
